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Dr. Berne's Whole Health Support

Dr. Berne's Optic Nerve Formula

$78.00

Dr. Berne’s Optic Nerve Formula is a synergistic formula designed to optimize nitric oxide (NO) levels in the body. The ingredients in this formula work to help promote the synthesis and discourage the degradation of nitric oxide, which is beneficial for cardiovascular function, eye circulation, and muscular performance.

Dr. Berne’s Optic Nerve Formula is a comprehensive formula designed to optimize nitric oxide (NO) levels in the body. It is provided in a delicious berry flavored powder for convenient dosing and ease of patient compliance.

This formula may be helpful for:

  • increasing the body’s production of NO
  • extending the half-life of NO in the body
  • protecting NO from producing peroxynitrites (harmful free radicals)
  • enhancing the production of ATP

Nitric oxide (NO) is a compound that influences the relaxation of blood vessels and healthy functioning of platelets, the cells and cell fragments responsible for proper blood clotting. For these reasons, NO plays an important role in cardiovascular health. Additionally, proper blood vessel dilation may facilitate increased blood flow to working muscles, with

the result being that these muscle cells may receive more oxygen and therefore generate energy more efficiently, ultimately supporting athletic performance. This formula may also support healthy erectile function, which is dependent on adequate blood flow to the penis. By promoting the body’s synthesis of NO and potentially prolonging the presence of NO in the blood, this product may favorably influence erectile function.

ALL SALES ARE FINAL - SORRY NO RETURNS OR REFUNDS

Benefits:

  • Facilitates blood vessel relaxation
  • Supports optic nerve and retinal circulation
  • May promote healthy erectile function
  • May increase blood flow to muscles, supporting athletic performance
  • Provides antioxidants; may aid in recovery from intense athletics

This formula contains a blend of ingredients to support production of NO and work synergistically to promote healthy blood vessel function.

  • Arginine and Citrulline: Arginine is an amino acid that serves as a precursor to NO. When arginine is made into NO, citrulline is produced and citrulline may be recycled back into arginine, thus supporting continued synthesis of NO. Much of the arginine in food is broken down in the intestine, with only about 50% reaching the circulation. For this reason, supplementing with arginine and citrulline may provide a more reliable supply of these NO building blocks.
  • Vitamin C: an antioxidant and also a required factor for building collagen, the primary protein that makes up the physical structure of blood vessels
  • Folate: a member of the B-vitamin family and a required cofactor for proper functioning of the enzyme responsible for synthesizing NO
  • Taurine: a natural diuretic; it also promotes a healthy heart rhythm and proper functioning of platelets
  • Magnesium: a natural blood vessel relaxant
  • Grape & Apple Extracts and Glutathione: Polyphenols in grape and apple extracts have potent antioxidant and vasodilating (blood vessel relaxing) properties, partly by facilitating production of NO. Tannins and anthocyanins— polyphenols found in grapes and apples, among other foods—may contribute to the well-known beneficial effects of moderate red wine consumption on cardiovascular health. Glutathione is often called the body’s “master antioxidant,” owing to its powerful ability to help neutralize harmful free radicals.
  •  

Preliminary studies show that Nitric Oxide may have some efficacy in both ocular hypertension and glaucoma.*

* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693832/

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

All Sales are Final.  Sorry,  No Refunds or Returns.
Recommended use: Mix 7 grams (approx. one scoop) in 8-10 ounces of water per day. 
 

Supplement Facts

Serving Size 7 grams (approx. one scoop)

 

 

Servings Per Container 30

 

 

 

 

 

Amount Per Serving

 

% Daily Value

 

 

 

Vitamin C (as Ascorbic Acid)

 

300 mg

333%

 

Folate (as Quatrefolic®

[6S]-5-methyltetrahydrofolate, glucosamine salt 200 mcg)

170 mcg DFE

43%

Pantothenic Acid (as d-Calcium Pantothenate)

100 mg

2000%

Magnesium (from Creatine MagnaPower®)

120 mg

29%

L-Arginine

1.5 g

*

L-Citrulline

1.5 g

*

Taurine

1 g

*

Creatine (from Creatine MagnaPower®)

675  mg

*

Grape Apple Extracts and

(Vitis vinifera)(fruit) (Malus pumila)(skin)

[standardized to contain 95% polyphenols]

250 mg

*

L-Glutathione (reduced) (as Setria®)

100 mg

*

 

 

 

*Daily Value not established.

 

 

Other Ingredients: Natural flavor, citric acid, stevia leaf extract (Stevia rebaudiana).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

 

Benefits of this formula:

Arginine and Citrulline

Arginine is a critical substrate for the synthesis of NO, a compound that relaxes endothelial cells throughout the cardiovascular system. NO also inhibits platelet aggregation and superoxide radical generation. Arginine supplementation has been shown to reverse the endothelial dysfunction associated with common cardiovascular risk factors and also ameliorates symptoms of certain cardiovascular disorders, including coronary and peripheral arterial disease, ischemia/reperfusion injury and heart failure.1

Supplemental arginine may be beneficial due to high arginase activity in the small intestine, where approximately 40% of arginine is degraded during digestion, and only 50% of dietary arginine enters the systemic circulation.1

Citrulline is included as an adjunct to arginine, as citrulline is converted to arginine in various cells. Unlike arginine, citrulline is not metabolized in the intestine or liver and does not induce tissue arginase. In fact, it inhibits arginase, and citrulline entering peripheral tissues—particularly the kidneys and vascular endothelium—may be readily converted to arginine, thus raising arginine levels and enhancing NO production.2 Studies show that citrulline raises plasma arginine levels significantly higher than arginine itself and has a longer half-life in the body, so citrulline can be thought of as a potent “time-released arginine.”3 Research suggests that one of citrulline’s primary physiological roles is serving as a precursor to arginine in the kidneys.4,5

In regard to the influence of citrulline on increasing NO synthesis and stimulating a positive downstream effect, a study involving men with mild erectile dysfunction demonstrated that 1.5 g/day of citrulline improved erectile function in 50% of participants.3

Cardiovascular health: by increasing NO production, endothelial cell function is improved, which causes blood vessel relaxation; supports normal blood pressure; supports sexual health by maintaining erectile function.

Athletic performance: by increasing blood flow to muscles and enhancing ATP production, exercise can be performed at a higher intensity for a longer duration; muscle contraction may be more efficient, potentially leading to a greater anabolic effect. Additionally, antioxidants in NOx SynergyTM may help aid recovery from intense athletics.

Folate, as 5-MTHF, is included as a precursor to tetrahydrobiopterin (BH4), a required cofactor for activity of the enzyme nitric oxide synthase (NOS).7 Inadequate levels of BH4 result in the generation of superoxide radicals, rather than NO, from endothelial NOS (eNOS).8 When low BH4 bioavailability occurs, oxygen activation is “uncoupled” from arginine oxidation, and NOS produces superoxide instead of NO. NOS-derived superoxide reacts with NO to produce highly reactive peroxynitrite radicals, which rapidly oxidize BH4 and trigger uncoupling of NOS. Depletion of BH4 and uncoupling of NOS may result in hypertension, ischemia/reperfusion injury, overload induced heart failure and atrial fibrillation.9 Sufficient folate is also required for proper metabolism of homocysteine.

Arginine and Citrulline

Arginine is a critical substrate for the synthesis of NO, a compound that relaxes endothelial cells throughout the cardiovascular system. NO also inhibits platelet aggregation and superoxide radical generation. Arginine supplementation has been shown to reverse the endothelial dysfunction associated with common cardiovascular risk factors and also ameliorates symptoms of certain cardiovascular disorders, including coronary and peripheral arterial disease, ischemia/reperfusion injury and heart failure.1

Supplemental arginine may be beneficial due to high arginase activity in the small intestine, where approximately 40% of arginine is degraded during digestion, and only 50% of dietary arginine enters the systemic circulation. 1

Citrulline is included as an adjunct to arginine, as citrulline is converted to arginine in various cells. Unlike arginine, citrulline is not metabolized in the intestine or liver and does not induce tissue arginase. In fact, it inhibits arginase, and citrulline entering peripheral tissues—particularly the kidneys and vascular endothelium—may be readily converted to arginine, thus raising arginine levels and enhancing NO production. 2 Studies show that citrulline raises plasma arginine levels significantly higher than arginine itself and has a longer half-life in the body, so citrulline can be thought of as a potent “time-released arginine.” 3 Research suggests that one of citrulline’s primary physiological roles is serving as a precursor to arginine in the kidneys. 4,5 In regard to the influence of citrulline on increasing NO synthesis and stimulating a positive downstream effect, a study involving men with mild erectile dysfunction demonstrated that 1.5 g/day of citrulline improved erectile function in 50% of participants. 3 NOx SynergyTM includes glutathione as an adjunct to citrulline. The combination of these compounds has been shown to increase plasma levels of NO in humans in vivo. It may be particularly beneficial for recovery from intense physical activity and may enhance muscle protein synthesis after resistance training.6

Grape (Vitis vinifera) and Apple (Malus pumila) Extracts
A proprietary combination of apple and grape polyphenols are included for their potent antioxidant and vasodilating properties. These polyphenols have been shown to enhance vasodilation by increasing the activation of the eNOS enzyme. Animal models and in vitro research have shown that polyphenols (including those from grapes and apples) are effective for increasing NO synthesis and availability by enhancing eNOS activity.11-14 Studies in humans confirm the health benefits of wine and grape polyphenols.15,16 This formula also includes vitamin C for its role in supporting healthy blood vessels. This nutrient is a required cofactor for building collagen, which is a key structural component of blood vessels. Additionally, working synergystically with the antioxidant compounds in grape and apple extracts, vitamin C exerts vasoprotective benefits, including helping to maintain capillary integrity.

Phloretin, a polyphenol most commonly found in apples, has been shown to inhibit the expression of inflammatory cytokine- induced adhesion molecules in aortic endothelial cells. It has also been demonstrated to reduce platelet aggregation, suggesting that phloretin could be protective against the onset and progression of cardiovascular disease.17 Other apple polyphenols inhibit expression of pro-inflammatory genes in human cells in vitro in a dose dependent manner.18

Taurine

This sulfonic acid derivative of cysteine has been shown to affect cardiovascular function through multiple mechanisms. It is anti-arrhythmic, hypotensive, and may decrease platelet aggregation.19 It also has a normalizing effect on cardiac muscle function with regard to calcium status, as it may strengthen contraction at low calcium levels, and beneficially relax the force of contraction at high calcium levels.20 Human and animal studies have shown taurine to reduce intimal thickening, arteriosclerosis, oxidative stress, and inflammation associated with diabetes, hypertension, and smoking-induced vascular events. Taurine supplementation in hypertensive patients has been shown to alleviate hypertension symptoms, as well as reverse arterial stiffness in type 1 diabetics.21 Taurine may also have a direct effect on NO by increasing eNOS expression, increasing plasma arginine concentration, and reducing synthesis of asymmetric dimethylarginine (ADMA), a NOS inhibitor.22

Chelated Creatine/Magnesium Complex

The combination of creatine and magnesium is a synergistic pairing of two compounds with powerful effects on cardiovascular health and muscle performance. The production of ATP involves the transfer of a phosphate group from creatine to ADP, and this transfer is dependent on the availability of magnesium ions. The chelated creatine/magnesium complex in this formula provides a stable, highly effective form of creatine with the presence of magnesium, wherein magnesium repletion facilitates the anabolic activity of creatine.

Magnesium is well-regarded for its hypotensive and relaxing effects, and a magnesium deficiency is associated with several conditions related to blood vessel function and blood flow.23 Creatine has long been recognized for its beneficial effects on muscle performance and lean body mass.24-27 Supplemental creatine stimulates strength and muscle mass, but its efficacy is limited by the lactamation reaction, which transforms some creatine into anabolically inert creatinine. Pairing creatine with magnesium inhibits this conversion, thus increasing the amount of creatine available for supporting muscle cells.

Supplementing with this creatine/magnesium chelate helps increase muscle strength as well as the speed of muscle mass growth, since larger amounts of ATP may facilitate greater force stimuli and muscle contraction. Creatine has also been demonstrated to increase muscle anaerobic capacity and aerobic recovery by stimulating mitochondrial activity.28 According to research, the effects of a combined magnesium/creatine chelate are significantly more potent than the administration of creatine and magnesium from separate sources.29,30 The effect of the anthocyanins in this product on NOS and oxidative stress may offer additional benefits for athletic performance as an ergogenic aid and to facilitate recovery.31,32

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References

  1. Guoyao Wu and Cynthia J. Meininger. Arginine Nutrition and Cardiovascular Function. J. Nutr. November 1, 2000 vol. 130 no. 11 2626-2629.
  1. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):275-90.
  1. Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22.
  1. Moinard C, Nicolis I, Neveux N, Darquy S, Bénazeth S, Cynober L. Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. Br J Nutr. 2008 Apr;99(4):855-62.
  1. Edzard Schwedhelm, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. Jan 2008; 65(1): 51–59.
  1. McKinley-Barnard S, Andre T, Morita M, Willoughby DS. Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis. Journal of the International Society of Sports Nutrition. 2015;12:27.
  1. Crabtree MJ, Channon KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide. 2011 Aug 1;25(2):81-8.
  1. Alp NJ, Channon KM. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):413-20.
  1. Alkaitis MS, Crabtree MJ. Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling. Curr Heart Fail Rep. 2012 Sep;9(3):200-10.
  1. Witte, Klaus, Clark, Andrew, and Cleland, John. Chronic Heart Failure and Micronutrients. Journal of the American College of Cardiology. 2001 Jun;37(7):1765-1774.
  1. Agouni A, et al. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PLoS One. 2009;4(5):e5557.
  1. Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch. 2010;459(6):853–862.
  1. Schini-Kerth VB, Etienne-Selloum N, Chataigneau T, Auger C. Vascular protection by natural productderived polyphenols: in vitro and in vivo evidence. Planta Med. 2011;77(11):1161–1167.
  1. Oak MH, Auger C, Belcastro E, Park SH, Lee HH, Schini-Kerth VB. Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium. Free Radic Biol Med. 2018;122:161–170.
  1. Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, Skaltsounis AL, Kremastinos
  2. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.
  1. Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation. 1999 Sep 7;100(10):1050-5.
  1. Stangl V, et al. The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets. J Nutr. 2005 Feb;135(2):172-8.
  1. Jung M, Triebel S, Anke T, Richling E, Erkel G. Influence of apple polyphenols on inflammatory gene expression. Mol Nutr Food Res. 2009 Oct;53(10):1263-80.
  1. Wu G. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids. 2020;52(3):329–360.
  1. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992 Jan;72(1):101-63.
  2. Abebe W, Mozaffari MS. Role of taurine in the vasculature: an overview of experimental and human studies. Am J Cardiovasc Dis. 2011;1(3):293-311.
  1. Guizoni DM, Vettorazzi JF, Carneiro EM, Davel AP. Modulation of endothelium-derived nitric oxide production and activity by taurine and taurine-conjugated bile acids. Nitric Oxide. 2020;94:48–53.
  1. Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013 May 1;4(3):378S-83S.
  2. Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003 Nov;17(4):822-31.
  1. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18.
  1. Buford TW, Kreider RB, Stout JR, et al. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr. 2007;4:6.
  1. Kreider RB. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003;244(1-2):89–94.
  1. Clark JF. Creatine: a review of its nutritional applications in sport. Nutrition. 1998 Mar;14(3):322-4.
  2. Brilla LR, Kennedy JS, Knutzen KM. Magnesium-creatine supplementation effects on exhaustive exercise. American Journal of Clinical Nutrition 2002. 75:419S.
  1. Brilla, L.R., Giroux, M.S., Taylor, A., and Knutzen, K.M. (2002) Magnesium-creatine supplementation effects on anaerobic power and fatigue. The FASEB Journal, pt. II, 16:A783.
  1. Kashi DS, Shabir A, Da Boit M, Bailey SJ, Higgins MF. The Efficacy of Administering Fruit-Derived Polyphenols to Improve Health Biomarkers, Exercise Performance and Related Physiological Responses. Nutrients. 2019;11(10):2389.
  1. Bowtell J, Kelly V. Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance. Sports Med. 2019;49(Suppl 1):3–23. doi:10.1007/s40279-018-0998-x

Dr. Berne's Optic Nerve Formula

$78.00
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