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Dr. Berne's Whole Health Support

Dr. Berne’s Whole Health Gallbladder Support


Dr. Berne’s Whole Health Gallbladder Support provides support for liver and gallbladder function
by providing lipotropic substances that aid in the elimination of fatty substances from the liver and promote proper bile flow.* The nutrients and herbal extracts in this product also support healthy detoxification pathways and optimal digestion and absorption of dietary fats and fat-soluble nutrients.* This product is ideal for individuals who need support for liver function, those who have had their gallbladder removed, and patients living with skin issues that may be helped by improved absorption of fat, particularly essential fatty acids.

  • Supports healthy digestion
  • Supports synthesis and proper flow of bile
  • Facilitates absorption of fat-soluble vitamins and phytochemicals (e.g., vitamins A, D, E, K and carotenoids)
  • Enhances glutathione activity
  • Provides hepatoprotective antioxidants
  • May help reduce the buildup of fat in the liver

Liver support

Methionine, vitamins B12 and B6 support methylation reactions critical for effective detoxification while methionine, vitamin B6 and artichoke help maintain healthy glutathione status.1 Additionally, as vitamin A precursors, the mixed carotenoids in this product, along with artichoke leaf extract, may induce sulfotransferase enzymes needed for detoxification. Dr. Berne’s Whole Health Gallbladder Support also contains the sulfur-containing amino acid taurine, which is crucial for phase II conjugation. 

Milk thistle (Silybum marianum) is one of the most well-researched protective herbs for hepatocytes and has even demonstrated the ability to promote the regeneration of liver cells in subjects with hepatitis and other liver disorders, possibly owing to increased hepatocyte protein synthesis.2,3 Milk thistle has also been shown to protect against liver cell injury from ethanol, acetaminophen, carbon tetrachloride or iron overload, and it inhibits the lipoxygenase enzyme, giving it antioxidant and anti-lipid peroxidation effects.3,4 Additional effects include aiding in bile flow, protecting against fibrosis, reducing the production of inflammatory cytokines, and potentially increasing insulin sensitivity.5

Inositol is another beneficial compound for the liver. Rodent models of non-alcoholic fatty liver disease (NAFLD) induced via a high-fructose diet show that inositol supplementation helps reduce the buildup of liver fat and expression of genes related to fatty acid synthesis.6 Rodent models of type 2 diabetes indicate that inositol supplementation (along with inositol hexaphosphate) increases liver reduced glutathione levels and reduces liver triglyceride accumulation and serum alkaline phosphatase activity while significantly increasing hepatic superoxide dismutase and catalase activity, resulting in the preservation of liver cell integrity and improved antioxidant status.7

Artichoke (Cynara scolymus) has been found to enhance glutathione peroxidase activity and decrease production of reactive oxygen species. In a randomized, placebo-controlled trial, patients with non-alcoholic steatohepatitis (NASH) treated with artichoke extract showed significant reductions in serum AST and ALT liver enzymes, total cholesterol, LDL-C, systolic blood pressure and blood glucose levels.8 Like milk thistle, artichoke has been shown to have antioxidant, choleretic and hepatoprotective properties and to potentially aid in the regeneration of liver cells.9

Beetroot (Beta vulgaris) is a valuable source of betaine (trimethylglycine), which can act to reduce fatty infiltration and degeneration of the liver, as well as help to thin the bile for improved gallbladder function.10,11 Rodent models of chemically-induced liver injury show that beetroot extract attenuates oxidative stress, inflammation and apoptosis in hepatocytes, increases levels of glutathione and other antioxidant enzymes, and attenuates the increase in lipid peroxidation, nitric oxide synthesis and pro-inflammatory cytokines seen in rodents not treated with beetroot.12,13 Research in human liver cell lines in vitro suggests that betanin, a major component of beetroot, is responsible for some of the hepatoprotective effects by activating the nuclear factor erythroid-2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway.14

Recommended Use: As a dietary supplement, take three capsules per day with meals, or as directed by your health care practitioner.


 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Customer Sheet

Dr. Berne’s Whole Health Gallbladder Support